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One in five Australian five-year-olds at risk of falling behind in school

New research has found that 22 per cent of Australian children are "developmentally vulnerable" at age five.


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One third of NT budget repair plans in place, one year after warnings of debt crisis

One year after releasing its plan to drag the NT budget out of structural deficit, the Labor Government says a third of its promises have been implemented in full. But some key measures are still in the works and the Opposition is demanding a better look at the books.


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One of the world's few micronations celebrates its 50th, but is the Hutt River Province dream over?

On this day 50 years ago, WA farmer Leonard Casley "stuck his nose up" at the Federal Government and seceded from Australia, forming the micronation the Principality of Hutt River.


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One year after its launch, Canberra's light rail patronage has plummeted

Light rail was officially launched one year ago in Canberra and, up until the COVID-19 outbreak, was proving more popular than first estimated. The government announced an increase in frequency to help alleviate the peak hour crush earlier this year, but now, the carriages are running empty.


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One in five Australian five-year-olds at risk of falling behind in school

New research has found that 22 per cent of Australian children are "developmentally vulnerable" at age five.


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One in five Australian five-year-olds at risk of falling behind in school

New research has found that 22 per cent of Australian children are "developmentally vulnerable" at age five.


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Only half of businesses prepared to return to pre-crisis levels after lockdown lifts

One in twenty businesses said they would be unable to viably operate as long as social distances measures are still enforced.


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Hospices still denied access to PPE as Health Secretary insists government is doing 'as much as we can'

One hospice ITV News spoke to is three days away from running out of protective gowns needed to treat patients with coronavirus.


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‘Incredible work’: B.C. agency’s mock ad for Ryan Reynolds’ Aviation Gin grabs actor’s attention

One Peak Creative, which started in Vancouver before moving to Kelowna, has created several mock ads during the coronavirus pandemic.


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The internationally-led publication outlines the climate emergency

One of the lead authors of the study says it outlines key indicators to track the depth and scale of climate change.


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One Plus One: Louise Herron


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One Dead and 5 Missing After Canadian Military Helicopter Crashes off Greece

The Cyclone helicopter was participating in a NATO training exercise. A Nova Scotia native died, and two others from the province were missing.


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One billion people will live in insufferable heat within 50 years – study

Human cost of climate crisis will hit harder and sooner than previously believed, research reveals

The human cost of the climate crisis will hit harder, wider and sooner than previously believed, according to a study that shows a billion people will either be displaced or forced to endure insufferable heat for every additional 1C rise in the global temperature.

In a worst-case scenario of accelerating emissions, areas currently home to a third of the world’s population will be as hot as the hottest parts of the Sahara within 50 years, the paper warns. Even in the most optimistic outlook, 1.2 billion people will fall outside the comfortable “climate niche” in which humans have thrived for at least 6,000 years.

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What to do if you have a dental emergency during lockdown

One of London's top dentists shares her tips on how to manage a dental crisis during the lockdown


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One Fine Stay offers free stays at its luxury homes to NHS workers

Forty of onefinesytay's London homeowners are offering stays in their homes to key workers for free


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OnePlus 8: wireless charging and 5G make this the company's most expensive range yet

The OnePlus 8 and 8 Pro both feature 5G tech and a shiny new camera set-up


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John Lewis launches free virtual personal styling service

One-to-one video chats to help you streamline your wardrobe


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One in three shareholders vote for Rio Tinto to adopt binding emissions target

Shareholder vote in favour of global mining giant adopting binding targets grew sixfold since last year

Shareholders in global miner Rio Tinto have rebuked the company over its climate stance, with 37% voting at a meeting in Australia for a resolution that would require it to set binding emissions targets.

While the resolution did not pass, its sponsor, environmental group Market Forces, said it attracted six times as much support as an identical one put up at the same meeting last year.

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One to watch: Jetta

The Liverpool singer-songwriter shifts effortlessly from alt-R&B to melodic, country-tinged pop

“You can be very creative using very little… I actually prefer having less to work with because that way you need to use more of your imagination,” the Liverpool-born Jetta told The Line of Best Fit last month. That spareness and sense of freedom is audible in her work, which she writes, records and produces herself. Her sound recalls the alt-R&B of Kelela or the xx, or the intimate balladry of Jessie Ware, but where mere copyists would hang endlessly on a yearning chorus and a dark blue mood, Jetta knows when to shift it up with a smart melodic left turn or a deft change of pace.

Now based in London, she’s been singing since she was four – her father was a recording engineer, her mother a choirmaster – and performing solo and singing backing vocals for the likes of Paloma Faith since she was 17, streamlining the powerful, punchy, soulful pop of her 2014 EP, Start a Riot, to a subtler, smokier style. That experience tells in her rich voice, the versatility of which recalls FKA twigs or Martina Topley-Bird. She switches easily from the bruised and contemplative Friend to the popping UK garage bop of Livin’ to the country-tinged, compulsive chime of forthcoming single I Wanna Know: a world of sound in a formidable one-woman operation.

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One Tree Hill's Hilarie Burton says she feels 'guilt' over not speaking out about sexual harassment sooner

Actor said she did not make her accusations public at first for fear of being labelled a 'troublemaker'


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One World: Together At Home review – a virtual Live Aid full of brilliance, boredom and buffoonery

A cornucopia of huge pop names came together for an unprecedented cultural and technological event


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One World: Jimmy Fallon takes swipe at Amazon CEO Jeff Bezos during charity concert

Late-night host revealed that more than $50m has been raised ahead of the One World event


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Boris Johnson ally Conor Burns resigns as minister after suspension from Commons for attempting to intimidate member of public

One of Boris Johnson's closest allies quit as a minister today after being found to have breached the MPs' code of conduct by trying to "intimidate" a company chairman involved in a loan row with his father.


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One For The History Books: 14.7% Unemployment, 20.5 Million Jobs Wiped Away

U.S. employers shed a record number of jobs in April, as the unemployment rate climbed to the highest since the Great Depression. The coronavirus crisis has locked down much of the economy.


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One in three nurses say mental health has become 'very bad' during pandemic

A lack of PPE is concern among nurses


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One Damn Thing After Another

Jan-Werner Müller

The long roots of liberal democracy’s crisis.

The post One Damn Thing After Another appeared first on The Nation.


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Arrivals in UK airports and sea ports 'to enter enforced quarantine for two weeks'

One trade body said the quarantine period would have a devastating impact on the UK aviation industry and wider economy


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One police officer killed and another critically injured after Texas helicopter crash

A police helicopter has crashed in Texas, killing one of the two officers on board and critically injuring the other.


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Chiltern Firehouse wins fight to open pavement café

One of London's most popular celebrity nightspots will be allowed to open a Parisian-style pavement café despite dozens of complaints from neighbours.


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Norwegian tycoon Tom Hagen held on suspicion of killing missing wife

One of Norway's wealthiest men is being held on suspicion of murdering his wife who has been missing since 2018.


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One World Together at Home: Little Mix and Tom Jones among stars paying tribute to NHS in global online concert

Little Mix, Michael Buble and Sir Elton John were among the stars playing tribute to the NHS in a special online concert.


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Dog owner discovers how hard it is to groom pets in lockdown after cutting Pomeranian's hair too short

One dog owner has found out the hard way that giving her Pomeranian a haircut at home during the coronavirus lockdown isn't an easy job.


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One in 11 Covid-19 deaths did not involve underlying health conditions, ONS statistics show

Read our live coronavirus updates HERE Coronavirus: The symptoms


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One in ten hospital nurses off sick with coronavirus symptoms or in isolation

Coronavirus: the symptoms Read our LIVE updates on the coronavirus here


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Google unifies messenger teams, plans “more coherent vision”

One person is now in charge of Google’s six messaging apps.


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Breaking Down the Two Tests That Could Help Contain the COVID-19 Pandemic

One detects an active infection; another signals that the virus has already left the body. Both are critical for tracking the spread of disease


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Study reveals foodborne illness burden in Taiwan

One in six Taiwanese people suffered from foodborne illness annually during a four year period studied by researchers. From 2012 to 2015, almost 3.9 million foodborne illnesses and 50 deaths occurred annually in the country. Scientists said the study, published in the Journal of the Formosan Medical Association, provided the first national estimates on the... Continue Reading


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Global push seeks to unlock genetic key of coronavirus' vulnerability

One of the mysteries of the coronavirus pandemic that scientists are trying to solve is why some people are barely affected while others who seem to be young and healthy become very sick.


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Crucial unveils P2 and P5 NVMe SSDs

One sounds far more promising than the other


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The Arsenal star who features in the top ten Premier League players for increased transfer value

One Arsenal star is on the list of the top ten Premier League players for increased transfer value in 2019.


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Portugal's low-income households struggle to survive pandemic

One in four Portuguese with a monthly household income of 650 euros ($705) or less have lost all their income because of the economic impact of the coronavirus outbreak, a study by the National School of Public Health showed on Saturday.


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Parrot Adds Folding VR Goggles to Anafi Drone Kit

One of our favorite consumer drones gets an FPV upgrade


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One Family’s Frantic Search to Get the Drugs to Combat COVID-19

Photo Illustration by The Daily Beast/Getty

Marissa Guale is like all too many Americans right now. Her husband and father of her two children, Raul, is on a ventilator in a hospital on Long Island, fighting for his life while sick with COVID-19. Raul, a 34-year-old nurse, likely caught the disease while working in a nursing home. When the National Institutes of Health announced an emergency use authorization for the experimental antiviral drug remdesivir, Marissa scrambled friends and family on Facebook to figure out how to get access for Raul, emailing hospital administrators, senators, and doctors. They pressed the Guale family’s case for a potentially lifesaving treatment on social media to anyone who would listen.

Her confusion about where and how to get access to the drug isn’t unique. All over the country, families, doctors, and hospitals are wondering how to get the drug and on what basis it’s being distributed. The Trump administration, which is in charge of allocation, hasn’t published any guidance on how it’s making decisions about the scarce supplies of the drug.

So who decides which hospitals get remdesivir? And what’s the most ethical way to prioritize access?

Read more at The Daily Beast.


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One Child Killed, 72 Others Sickened by Coronavirus-Linked Syndrome in New York

The majority of these children have tested positive for the virus or seem to carry antibodies from an earlier infection.


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One Size Does Not Fit All: Marked Heterogeneity in Incidence of and Survival from Gastric Cancer among Asian American Subgroups

Background:

Asian Americans are at higher risk for noncardia gastric cancers (NCGC) relative to non-Hispanic Whites (NHW). Asian Americans are genetically, linguistically, and culturally heterogeneous, yet have mostly been treated as a single population in prior studies. This aggregation may obscure important subgroup-specific cancer patterns.

Methods:

We utilized data from 13 regional United States cancer registries from 1990 to 2014 to determine secular trends in incidence and survivorship from NCGC. Data were analyzed for NHWs and the six largest Asian American subgroups: Chinese, Japanese, Filipino, Korean, Vietnamese, and South Asian (Indian/Pakistani).

Results:

There exists substantial heterogeneity in NCGC incidence between Asian subgroups, with Koreans (48.6 per 100,000 person-years) having seven-fold higher age-adjusted incidence than South Asians (7.4 per 100,000 person-years). Asians had generally earlier stages of diagnosis and higher rates of surgical resection compared with NHWs. All Asian subgroups also demonstrated higher 5-year observed survival compared with NHWs, with Koreans (41.3%) and South Asians (42.8%) having survival double that of NHWs (20.1%, P < 0.001). In multivariable regression, differences in stage of diagnosis and rates of resection partially explained the difference in survivorship between Asian subgroups.

Conclusions:

We find substantial differences in incidence, staging, histology, treatment, and survivorship from NCGC between Asian subgroups, data which challenge our traditional perceptions about gastric cancer in Asians. Both biological heterogeneity and cultural/environmental differences may underlie these findings.

Impact:

These data are relevant to the national discourse regarding the appropriate role of gastric cancer screening, and identifies high-risk racial/ethnic subgroups who many benefit from customized risk attenuation programs.


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In utero MRI identifies consequences of early-gestation alcohol drinking on fetal brain development in rhesus macaques [Neuroscience]

One factor that contributes to the high prevalence of fetal alcohol spectrum disorder (FASD) is binge-like consumption of alcohol before pregnancy awareness. It is known that treatments are more effective with early recognition of FASD. Recent advances in retrospective motion correction for the reconstruction of three-dimensional (3D) fetal brain MRI...


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ONE-HELIX PROTEIN1 and 2 Form Heterodimers to Bind Chlorophyll in Photosystem II Biogenesis

Members of the light-harvesting complex protein family participate in multiple processes connected with light sensing, light absorption, and pigment binding within the thylakoid membrane. Amino acid residues of the light-harvesting chlorophyll a/b-binding proteins involved in pigment binding have been precisely identified through x-ray crystallography experiments. In vitro pigment-binding studies have been performed with LIGHT-HARVESTING-LIKE3 proteins, and the pigment-binding ability of cyanobacterial high-light-inducible proteins has been studied in detail. However, analysis of pigment binding by plant high-light-inducible protein homologs, called ONE-HELIX PROTEINS (OHPs), is lacking. Here, we report on successful in vitro reconstitution of Arabidopsis (Arabidopsis thaliana) OHPs with chlorophylls and carotenoids and show that pigment binding depends on the formation of OHP1/OHP2 heterodimers. Pigment-binding capacity was completely lost in each of the OHPs when residues of the light-harvesting complex chlorophyll-binding motif required for chlorophyll binding were mutated. Moreover, the mutated OHP variants failed to rescue the respective knockout (T-DNA insertion) mutants, indicating that pigment-binding ability is essential for OHP function in vivo. The scaffold protein HIGH CHLOROPHYLL FLUORESCENCE244 (HCF244) is tethered to the thylakoid membrane by the OHP heterodimer. We show that HCF244 stability depends on OHP heterodimer formation and introduce the concept of a functional unit consisting of OHP1, OHP2, and HCF244, in which each protein requires the others. Because of their pigment-binding capacity, we suggest that OHPs function in the delivery of pigments to the D1 subunit of PSII.


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One Dose of HPV Vaccine May Protect Against Cervical Cancer

Title: One Dose of HPV Vaccine May Protect Against Cervical Cancer
Category: Health News
Created: 2/10/2020 12:00:00 AM
Last Editorial Review: 2/10/2020 12:00:00 AM


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Diagnosing Mild Cognitive Impairment in Women

One problem with memory tests is that cut-off scores for mild cognitive impairment don’t reflect that women tend to have stronger verbal memory than men.


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